The COVID-19 pandemic has taken a devastating toll on global health, and unfortunately, the situation is not showing signs of improvement in the near future. A new variant, known as JN.1, has emerged, and it is causing great concern among experts. This variant is highly transmissible and has unknown pathogenesis, meaning we are still trying to understand how it affects the body. Preliminary data suggests that individuals infected with the JN.1 variant may experience severe medical conditions such as strokes, organ failures, and various types of cancer.
In addition to these serious physical health effects, there is also a rise in SARS-CoV-2-induced neurodegenerative and mental health issues. While many individuals may not die immediately during the acute infection phase, there is expected to be a significant increase in deaths in the aftermath. This will lead to excess mortality rates in the year 2024. The constant reinfections and the evolution of the JN.1 variant into numerous sub-lineages with different mutations are contributing to this alarming rise in mortality.
Unfortunately, mainstream media may downplay the seriousness of these surges and fail to provide accurate coverage of what is truly happening. It is crucial for the public to stay informed and seek reliable sources of information to understand the gravity of the situation.
The JN.1 variant is rapidly evolving to evade various forms of immunity, including those elicited by vaccines, previous exposures, and antiviral medications. It is also adapting to environmental factors such as temperature, humidity, pH, UV exposure, and disinfectants. Some of the new sub-lineages may not currently have the viral fitness to become predominant, but they are evolving at a rapid pace. Several of these JN.1 spawns, such as JN.1.1, JN.1.1.1, JN.1.2, JN.2, JN.4, JN.6, JN.8, and JN.9, are already showing potential to cause continuous surges. What’s even more concerning is that infections with the JN.1 variant do not provide protection against its spawns, which are even more immune evasive.
Among these spawns, the JN.1.1 sub-lineage is predicted to become the next predominant variant due to its rapid spread. While there is speculation that the JN.1.1 variant may drive disease severity, experts are urging us to focus on the threat posed by the new spawns with the T572I spike mutation. This mutation, found in several JN.1 spawns, enhances the binding of the virus to the ACE2 receptor, potentially increasing infectivity and pathogenesis.
Though the outlook may seem bleak, experts suggest that a shift may occur between March and May 2024. A more lethal strain is projected to emerge, which could potentially lead to the eradication of 25 to 30 percent of the world’s population. Subsequent strains may then contribute to the intended depopulation outcomes. It is of utmost importance to stay informed about these developments, and Thailand Medical News will continue to provide updates on this impending catastrophe.