A new study has raised concerns about liver injuries in individuals who received the Pfizer-BioNTech COVID-19 mRNA vaccine. The study, conducted by over 50 renowned medical and research institutions, examined cases of liver injuries following SARS-CoV-2 vaccination. Out of 87 patients with liver injuries, 59% of cases were linked to the Pfizer vaccine.
Liver injury was typically diagnosed around 15 days after vaccination, indicating a delayed onset of symptoms. Most cases involved damage to the liver cells, known as hepatocellular injury. Additionally, many patients showed signs suggestive of immune-mediated hepatitis.
Corticosteroid therapy was given to 53% of patients, with a higher percentage receiving treatment for more severe liver injuries. Patients with immune-mediated hepatitis were more likely to receive corticosteroids. Fortunately, the majority of patients had a favorable outcome, with their liver injuries resolving. However, one patient experienced fulminant liver failure and required a liver transplant.
These findings highlight the need to recognize and address the risk of liver injury following vaccination. Corticosteroid therapy has emerged as a potential intervention for severe hepatitis or immune-mediated features. It is essential for healthcare professionals to remain vigilant about potential adverse effects, and for individuals to be aware of the signs and symptoms of liver injury.
As the global vaccination campaign against COVID-19 continues, ongoing research and surveillance are crucial to refine vaccination strategies and ensure the safety of individuals worldwide. Monitoring the occurrence of liver injuries and understanding the underlying mechanisms can help inform vaccine administration protocols and optimize patient care.